Marvel's Ultimate Spider-Man (2012)

S02E01 The Lizard

Title: The Lizard Plot: Spider-Man swings back into action to thwart Doctor Octopus's evil scheme. However, things take an unexpected turn when his ally, Dr. Curt Connors, undergoes a shocking transformation into The Lizard. As chaos unfolds, Spidey must confront both his old nemesis and the monstrous side of his friend.