It's Garry Shandling's Show (1986)

Garry Shandling plays a fictionalized version of himself, a witty and anxious stand-up comic fully aware of his existence within a sitcom. He frequently breaks the fourth wall, engaging directly with the studio audience while delivering sharp monologues and wrapping up each episode with entertaining recaps. The unique twist lies in the fact that not only Garry knows they’re on a TV show; the audience also becomes an integral part of the narrative, blurring the lines between performer and viewer. This groundbreaking series cleverly combines humor with meta-commentary on television itself.